The role of Ca in wound healing was recognized very early. Robert
Chambers (New York University) and L.V. Heilbrunn (University of
Pennsylvania) both worked with marine eggs many summers at the Marine
Laboratory at Woods Hole. Chambers was known for
micromanipulation and microinjection experiments. Heilbrunn called the
wound healing process the "surface precipitation reaction" and was the
first to propose the central role for Ca in cell physiology.
overview of their work, see "Explorations into the Nature of the Living
Cell" by Chambers and Chambers (Harvard University Press, 1961), and
"The Dynamics of Living Protoplasm" by Heilbrunn (Academic Press, 1956).