The role of Ca in wound healing was recognized very early. Robert Chambers (New York University) and L.V. Heilbrunn (University of Pennsylvania) both worked with marine eggs many summers at the Marine Biological Laboratory at Woods Hole. Chambers was known for micromanipulation and microinjection experiments. Heilbrunn called the wound healing process the "surface precipitation reaction" and was the first to propose the central role for Ca in cell physiology.

For an overview of their work, see "Explorations into the Nature of the Living Cell" by Chambers and Chambers (Harvard University Press, 1961), and "The Dynamics of Living Protoplasm" by Heilbrunn (Academic Press, 1956).

Robert Chambers

L.V. Heilbrunn